Abstract Bispecific T cell engagers (BiTEs) are an innovative class of immunotherapeutics that Over-Ear redirect T cells to tumor surface antigens.While efficacious against certain hematological malignancies, limited bioavailability and severe toxicities have so far hampered broader clinical application, especially against solid tumors.Another emer

Many membrane proteins RESPIR ESSENCE fold inefficiently and require the help of enzymes and chaperones.Here we reveal a novel folding assistance system that operates on membrane proteins from the cytosolic side of the endoplasmic reticulum (ER).We show that folding of the Wnt signaling coreceptor LRP6 is promoted by ubiquitination of a specific ly

The activated TIG (ATIG) welding process mainly focuses on increasing the depth of penetration and the reduction in the width of weld bead has not been paid much attention.The Over-Ear shape of a weld in terms of its width-to-depth ratio known as aspect ratio has a marked influence on its solidification cracking tendency.The major influencing ATIG

Sixty germplasm accessions of Cenchrus ciliaris and Cenchrus setigerus were collected from different habitats in and aroundCoimbatore and Erode districts and planted in field trials.Based on initial morphological evaluation, four accessions fromCenchrus setigerus and three accessions from Cenchrus ciliaris Headband showed better biomass.Among the c

Spinocerebellar ataxia is a phenotypically and genetically heterogeneous group of autosomal dominant-inherited degenerative disorders.The gene mutation spectrum includes dynamic expansions, point mutations, duplications, insertions, and deletions of varying lengths.Dynamic expansion is the most common form of mutation.Mutations often result in indi